Auto Insurance Coverage:? Purchase as much liability coverage as you can.? Also, purchase as much underinsured coverage as you can because there is a greater risk that someone with inadequate coverage will hit you.
Home Owner?s Policy:? Purchase as much liability coverage as possible.? Also, purchase an umbrella policy because you can get a lot of coverage ($1 million to $2 million) for a modest amount of money.
Wills: If you die without a will, the State of North Carolina writes you one.? It is cheaper and easier to administer an estate where there is a will.
Durable Powers of Attorney:? If you are incapacitated, it allows you to name someone to pay bills and handle business or property transactions for you.? Your spouse may not be able to make certain financial decisions for you without this document.
Living Wills and Health Care Powers of Attorney:? A living will is a legal document in which you direct whether life prolonging medical procedures will be taken in certain circumstances.? A health care power of attorney is a legal document in which you appoint another person or persons who can consent to or refuse medical or mental health treatment if a physician or eligible psychologist determines you are unable to make or communicate these decisions for yourself.
Warranties about a purchase you are about to make:? The promise needs to be in writing to be worth anything.? Use your best judgment as to whether the warranty is worth the price.
How to avoid many common disputes with service people with whom you deal (home repair, construction, auto repair and others):? Have a clear understanding about the scope of the work and the price. Make sure you have a written contract.?
What to do if you are in a wreck:? Call the police.? Take pictures; get the other person?s information; be careful about what you say.
Contracts to buy real estate/ refinancing your mortgage: Get it in writing.? Make sure your closing costs do not exceed your savings; generally 1 percent less or more is worth refinancing.
Co-signing on a debt:? Do not do it.? If the other person cannot pay, you are liable.?
Many people are often anxious about considering elder care for their loved ones, but the truth is that elder care provides a variety of necessary services to those in need.? A family is often unable to provide the necessary help required to support their loved ones in their time of need.? However, elder care at home addresses the needs of everyone by providing the convenience and comfort of a home care companion at an affordable cost.? Take a look at just a few of the ways that in-home elder care can help your family:
Security
Seniors typically have less physical, emotional, and economic reserves to insulate them from the impacts of criminal activities or serious accidents.? In-home elder care offers the protection and support of another person at their side when others may have too many obligations to consistently ensure their safety.
Individual Care
An in-home elder care service offers one-on-one supervision and interaction for your loved one.? A home care companion works with them to ensure both their comfort and peace of mind.
Housekeeping
Due to a variety of factors, elderly people may suffer from debilitating conditions that inhibit their ability to perform simple functions.? In-home elder care focuses on helping your loved one maintain their independence while providing them with necessary services to ensure their good health.
Cost
Independent caregiving can be a significant investment of your physical, economic, and psychological resources.? While you should never hesitate to consider all of the best care options for your loved one, in-home elder care can ease the responsibility of independent caregiving and is often more affordable than comprehensive assisted living facilities.
Executive Home Care is a family-owned and operated senior home care business that has been providing in-home elder care for families in the Los Angeles area for over a decade.? With BBB-accreditation and several experienced professionals, we are committed to maintaining high-quality service for all of our clients.? Call one of our specialists at (310) 859-1555 or contact us online to inquire about our rates and services.
If a newbie on the internet home based business proprietor offers most the above mentioned features, or even may devote on their own in order to attaining all of them, they might be successful. Along with sufficient generate as well as enthusiasm, company abilities could be discovered. Starting an effective on the internet home based business might not be because much fetched as it might appears.
Before quitting your day work as well as getting the actual dive right into a home based business, nevertheless, here are a few points to consider. The greater products within the subsequent checklist that the starting house business owner offers, the greater prosperous these people could be.
Online home based business proprietors should:
Have sufficient self-discipline to produce as well as adhere to the self-appointed normal workday. Have the ability to individual individual existence through company existence. Have great management abilities as well as individual generate. End up being prepared as well as in a position to withstand extended hours associated with effort prior to the company gets completely functional. End up being psychologically prepared to cope with danger. Have the ability to hold off gratifications, waiting around many months prior to switching the revenue. Have the ability to determine the firms specific specialized niche as well as client bottom. Possess understanding or even knowledge for the reason that market, or even are prepared to discover. Understand cost their own item from higher sufficient produce sufficient income. Have the ability to have the cash required to open up as well as run the house company without having developing a individual income issue. Have the ability to strategy forward after which perform individuals programs. End up being inspired as well as regimented sufficient to complete all the needed function, all the time, rather than watching television, reading through the guide, getting on house work, or even involving in most distraction. Produce a house atmosphere that is favorable in order to effective function. Possess great business abilities as well as a watch with regard to fine detail. You will find absolutely no security netting whenever running a home based business. End up being customer support focused as well as prepared to consider the additional actions required to maintain clients pleased as well as obtain brand new types.
These benefits are extremely persuasive. This is exactly why increasing numbers of people appropriating the actual possibilities that the on the internet house companies offers.
You will find absolutely no employers in order to are accountable to. There isn?t any travel. The actual speed as well as function several hours tend to be versatile. There isn?t any gown signal. It is almost always simpler to stability each individual as well as expert life.
When in operation, there isn?t any someone to assist remain on monitor. Bad preparing, or even insufficient follow-through, may result in failing and also the obligation lay squarely using the home based business proprietor. Nevertheless, there are many benefits in order to running a home based business:
Running a good on the internet home based business in the event that different through employed by another person. Whilst a home based job might seem such as heaven, there are some points to consider prior to getting the actual dive.
Owning a good on the internet home based business in the event that different through employed by another person. A home based job might seem ideal, however there are some points to consider.
Universal and Montecito Picture Co. are hoping to develop a doozy of a follow-up to the 1988 hit comedy that starred Arnold Schwarzenegger and Danny DeVito that would reunite the two stars.
But wait, there?s a twist: In the new scenario, Eddie Murphy would act as a third brother.
PHOTOS: Modern film & television comedians
Titled "Triplets," the story would see Schwarzenegger and DeVito as brothers Julius and Vincent, conceived experimentally, who discover they have third sibling.
The project doesn?t have a director at this early stage -- Ivan Reitman, who helmed the original, would only act as a producer with his Montecito Picture Co. cohorts Joe Medjuk, Tom Pollock and Ali Bell, according to sources -- but the hunt is on for writers to develop the idea. Insiders caution that no substantial creative discussions have taken place between Universal and Montecito.
The actors are attached to star.
This wouldn?t be the first sequel to an 1988 film that Universal is working. The studio is developing a sequel to "Midnight Run" that sees Robert De Niro, one of the film?s two original stars along with Charles Grodin, returning in an incarnation to be directed by Brett Ratner.
?The rising acceptance involving facial dental treatment fear relief helps make it highly basic which will acquire a dental practitioner when it comes to all your location. Even so, to make sure you uncover an important dentist?s that will is simply greatly qualified may get hard. Basically no you prefers to actually panic cosmetic dentist san diego which experts claim their particular by mouth perform can turn out to be discouraged. For you to assure any kind of beneficial vanity treatments working experience, this can be fundamental to make sure you make sure people conduct the anticipated homework.
Just what exactly can be Dental Dentistry?
The actual fundamental plan involving cosmetic dental dentistry might be so that you can help many people decide to put their perfect be happy dentist in west palm beach in front. Procedure count several simulacre connected with dentistry many of these as being tooth enamel whitening, complaisance having to do with about veneers and therefore bubble gum re-shaping. The relevance about consuming the time to successfully discover your doctor in your own part exactly who are leaders on like operations is certainly vital to assist you to his / her achievement. Once the idea arrives for you to the tooth enamel and also typically the health and fitness involving the mouth area, everyone must not take on all probability.
Anyone a suitable Dentists inside Your own Vicinity
Furthermore there happen to be plenty of methods to make sure you ending the latest dental dental practice in your actual space. The particular the vast majority of normal and therefore probably recommended techniques usually are using your Web and also options. Found in the present day advice grow old, just relating to absolutely everyone includes a good solid page replete using make contact with ideas. Mainly because this type of, countless vanity dental surgeons on ones own community might possible now have an individual?s purchase webpages.
In order to really identify an actual oral surgeon website, conduct some sort of primary searching with regard to Yahoo and google or else virtually any many other msn search. Variety during any keywords, ?cosmetic dentist professionist? then this name for your favorite urban centre as well as most people is going to be happy available at all the variety involved with strikes. Implementing a Electronic, people have the ability to los angeles car accident attorney even ending a good vanity hygenist with regard to your personal section just by visiting a powerful on the web directory of dental practitioners.Chat in order to people whom possess consumed the actual same treatments fascinated present in. On one occasion you really recognize of which an important mate has got recently been to assist you to a good vanity dentist professionist, right now there is normally basically no problems in demanding to get your designate from his or her?s dental care cleaner. By means of this particular contact one would probably own found firsthand special expertise thus to assist you to talk among the tooth cleanings skills.
Less than 48 hours after teasing us with promises of upcoming "awesome new features," ASUS is now delivering the refresh to Transformer Primes in the UK. Via its Euro Facebook page, the Taiwanese outfit has announced that all TF201 owners in the United Kingdom can expect to see the OTA update anytime now. With the fresh ICS version, you'll be able to tinker with notifications in the lockscreen, connect to Ethernet via USB (adapter not included) as well as get support for wireless ad hoc mode. Unfortunately, TF101 owners will have to exercise some patience, as ASUS says the update for the elder Transformer is still in the works.
Update: According to folks in the comments (and our own Transformer Prime's notification pop-ups) the update is now rolling out stateside.
Starting a business? One of the first steps you will take towards establishing a solid business plan and foundation will be legally incorporating your business entity. Determining which legal structure is right for you and your startup is crucial, and will play a significant and consistent role throughout the duration of your company?s lifetime, especially when it comes to how your business will be taxed. The three most popular forms for small businesses are C corporations, S corporations, and Limited Liability Companies, more commonly known as LLCs. Every entity type has their advantages as well as disadvantages. It is important that you are knowledgeable on how each type will affect your company structure, as well as your bottom line. ?Give us a call today if you would like for one of our accountants to walk you through this process!
?
C Corporations: When a small business incorporates, it automatically becomes a C corporation, also known as a regular corporation. A C corporation is legally viewed as an individual entity, meaning an entity separate and apart from its owners, who are referred to as shareholders. Since a C corporation is legally viewed this way, the IRS views ?it this way as well, making this corporation type eligible for double taxation; once as a corporation, and then again as a shareholder when dividends are distributed.
When entrepreneurs are faced with the decision of which entity type to incorporate under, many view this as a huge downfall of choosing a C corporation.? However, if you do choose a C corporation, double taxation is not an inevitable fate. If owners who are working for the business are taking reasonable salaries for themselves, the corporation can deduct these salaries, allowing for the owners to pay taxes on the money they receive. The passing of the Jobs and Growth Relief Reconciliation Act in 2003 allowed for lower tax rates on dividends and has eased the impact of double taxation.? Also, there is limited liability offered under the C corporation option. Shareholders are only personally liable to the extent of their holdings in the corporation. As opposed to business forms such as partnerships or sole-proprietorships, their personal assets are not on the line. Another upside to a C corporation is that there are more incentives to attract investors, due to the fact that they have available stock to sell and there is an opportunity for dividends. Other advantages include the ability to deduct fringe benefits, and the continuance of existence, which means that transfer of stock or death of an owner, will not affect the corporation.
However, if you still feel as though the C corporation is not the right fit for you and/or your small business, if your business qualifies, you can choose S corporation status upon incorporation.
?
S Corporations: S corporations, whose name is derived from electing Subchapter S of the Internal Revenue Code, is popular among many business owners because it allows a corporation to avoid double taxation. Generally an S corporation does not pay federal corporate taxes; selecting subchapter S allows a business to pass all income, losses, deductions, etc., directly to shareholders, whom will then be liable for claiming tax responsibility on their personal tax returns. This allows the corporation to bypass being taxed as a separate entity.
However, not all corporations are eligible to become an S corporation. The company must have no more than 75 investors, who all must unanimously agree to the decision and sign the necessary paperwork, and all investors must be US residents or citizens. Also, certain types of companies are restricted to filing Subchapter S tax election by the IRS.
The major benefit of forming an S corporation is avoiding the double taxation impact experienced under C corporation status. However, S corporations have their downfalls as well; paying taxes on ?absent? income, eligibility to be taxed on fringe benefits, and liability for state, as well as, local taxes.?? Another thing for S corporations to watch out for is ensuring that the salaries paid out to those stockholders who are working for the corporation are ?deemed reasonable? by industry standards. If they are not, the IRS can require stockholders to pay payroll taxes on total income received from the corporation.
?
Limited Liability Company (LLCs): The Limited Liability Company is looked at as somewhat of a mix between a partnership and a corporation. The main difference between corporations and an LLC is that LLCs are usually taxed the way that partnerships are. Owners of an LLC are referred to as members; members may be individuals, corporations, or other LLCs or entities. Similar to an S corporation, an LLC provides limited liability and allows for all income, losses, deductions and credits to be passed on to the owners, allowing LLCs to avoid double taxation as well. ?Members may allocate these items any which way they like, providing much more tax flexibility then corporations. The structure of an LLC is not as restrictive as that of an S corporation, making Limited Liability Companies a very popular option for startup companies. Seeing as they are similar to partnerships, they allow much more management flexibility as well.
Before deciding if an LLC is the right choice for you and your small business, be sure to remember that rules and regulations regarding LLCs differentiate in every state. Make sure your state regulations are a right fit for you as well. It is also important to keep up with the laws regarding Limited Liability Companies, being that they are a fairly new practice in the US; legal standards are still being perfected. Also keep in mind, there are some businesses that do not qualify to for LLC status, such as banks, insurance companies, and nonprofits.
?
Each type of business structure has their advantages and disadvantages. It is important to find which structure will be the right fit for you and your small business. Understanding the tax code and laws applicable to each can be a challenging task. Be sure to thoroughly discuss all of your options with your CPA before moving forward with incorporating your business. If you need a CPA, tax advice, or help incorporating, call Corporate Tax Network at 866-893-5730! Also, be sure to follow us onFacebook,?Twitter, and?Google+ for more small business and tax tips!
?
Tags: Clearwater, Corporate Tax Network, CTN, Entrepreneur, Financial Services, Florida, Incorporating, New York, New York City, Small Business, Startups, Tax Preparation
This entry was posted on Tuesday, March 27th, 2012 at 12:43 pm and is filed under Uncategorized. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
NEW YORK (AP) ? Companies that want to come up with the tests used to measure New York City students' progress are being advised to stay away from topics including aliens and vermin.
A Department of Education list of subjects to avoid also includes: junk food, birthdays, abuse, terrorism, holidays and Halloween.
The department included the list in a recently issued request for proposals to create the tests used to measure student progress in math, science, literacy and social studies. It says the listed topics could "evoke unpleasant emotions" or "appear biased."
New York University education professor Diane Ravitch says concern about test topics isn't confined to the nation's largest city. She says it's something "testing companies have been doing for a long time."
Companies have until April 23 to submit their proposals.
Although every individual case is different, workers compensation is one aspect of insurance law that is generally well received by both employees and employers. It can seem rare that conflicting sides of an insurance claim would see eye to eye, but this is usually the case for workers comp. Obviously there may be disputes over claim amounts or other details, but it would be difficult to find anyone who disagrees altogether with the policy. This is because the mechanics of the law are well balanced so that both parties have something to gain.
Both Sides Have Something to Gain
Employees generally feel supported by workers compensation law because it provides a safety net in the case of accident or injury. The injured worker is guaranteed certain reimbursements for medical expenses incurred, lost wages, and so on. In this way, the employer provides an extra degree of health insurance and/or life insurance, and workers feel protected.
Employers gain something as well. In exchange for financial support, the injured employee agrees not to pursue legal action against the employer. This helps the organization avoid unbridled legal expenses, wasted time, and other hassles. Although disputes may arise over amounts or other payment conditions, in general most people who have had occasion to experience the system are basically content with the provisions of the law. To understand how this happy balance was struck, it is necessary to take a look back at how the system functioned before.
The Roots of Worker Compensation Law
Australia is unique in the world because the nation experienced labor reform very early. Organized unions were responsible for effecting pressure on industry as early as the late 19th century. Consequently, workers compensation laws here were some of the first around the world. Before these laws, employees had only one recourse against negligent employers: suing them in a court of law. While this may seem reasonable on paper, one must remember that average worker back then, and to a large degree today as well, would have been unable to hire lawyers and otherwise invest in a protracted legal battle. Even if they were able to cobble together a case, employers usually won anyway thanks to superior influence with the courts and deep pockets. On top of these disadvantages, an injured worker would have had to concentrate on finding other income sources immediately. A legal battle was not a realistic option; real recourse for injured persons was very limited indeed.
Despite the serious imbalance of the system, it did occasionally happen that injured workers would succeed in court. In these rare cases, there was no limit to the awards that could be granted, and so industry could potentially face significant loses thanks to successful claims. Despite this, big industry would probably have obstructed workers compensation laws had it not been for increasing pressure from ever more influential unions around the dawn of the 20th century. Because of these pressures, however, industry acquiesced as they began to see the writing on the wall. In then end, the battle was not extraordinarily difficult because employers, after all, did gain a guarantee against run-away prosecution. In the days when furious unions were taking the streets in Melbourne and Brisbane, this must have offered a certain amount of relief.
In the end, workers compensation laws offer a particularly harmonious balance with something to offer both workers and employers. Injured workers gain financial support to help them through difficult times. This is all most employees are interest in anyway. Businesses are able to continue with normal operations without fear of expensive and time-consuming law suits. An extra added benefit of this law, and perhaps the most positive result of the whole story is that both workers and employers are presented with good motivation to keep working conditions safe and to avoid hazardous situations. These laws signify for all parties concerned that risky conditions equal extra expense and wasted time. In Australia, at least, this is one area where workers and employers tend to agree.
The western diet plan, as decades go on has become a lot more dependent on the advantage of grains and so on and we are acquiring less omega 3 fatty acid (which you?ll get via flaxseed meal, flax oil and fish oil). This mix is pro-inflammatory which could go a way to clarify countless scenarios of inflammatory issues such as coronary heart disease. Just what exactly can we do about it?
We involve two healthy fats from our meal plans as well as the carbohydrates, proteins, minerals and vitamins. These fats are collectively named critical fatty acids (EFA?s) because we can not produce them ourselves plus they are known as omega 3 and omega 6. Omega 3 is transformed by our fat burning capacity into hormone like substances e.g. 3 sequence prostaglandins and leukotrienes. The hormone like chemicals derived from omega 6 fatty acids make irritation in our bodies whereas the chemicals that start out as omega 3 decrease inflammation.
If the ratio of those oils is just too superior (excess omega 6 to omega 3), we raise the probability of manufacturing inflammatory ailments such as coronary heart disease. Flax seed (possibly Flaxseed Meal or flax seed oil) offers just one of the best amounts of omega 3 essential fatty acid out of all non-animal resources.
It?s been famous (1) that signs or symptoms associated with chronic inflammatory disorders strengthen enormously if the ratio of omega 6 to omega 3 fatty acids is anywhere near 2-3/1. Consider that high omega 6:omega 3 is pro-inflammatory, and then consider notice that a ton of western diet programs have ratios of 15-16/1! Should you aren?t consuming quite a lot of oily fish, obtaining the appropriate harmony of EFA?s could be tough with out supplementation.
So when you have to have to dietary supplement for getting far more great ranges of omega 3, just how much Flaxseed Mealor oil or fish oil would you eat? are there any scientific solutions offered to aid ascertain this? The one particular method I am mindful of makes use of the ratios of EFA?s in the partitions of our red blood cells. These final results give an concept of the amount of correction your food plan demands and the way many mg/grams of omega 3 you require and so on. Your doctor the finest put to start should you have an interest.
If that every one seems to substantially hard function then growing your ingestion of EFA?s through consuming additional flax seed meal or oil or fish oils will help however you have to chat on your medical doctor about what amount flax or fish oil to take in if you already have a chronic problem e.g. the need of blood thinning prescription drugs or have a bowel complaint.
Just one final thought if you believed all fats are undesirable so you will have to avoid all fats I?d very first remind you that you will find two fats which are necessary for your health and in addition look at the Inuits. They?ve got large extra fat meal plans; whale meat and seal blubber and salmon and so forth and they have a lower occurrence of heart disease. It can be thought that just one of the contributing components is the higher amounts of omega 3 oil from the fish they consume. Flax Seed meal, flax oil and fish oils could hence assistance you in a equivalent way.
Chanduriya Vakhdole, the writer of this bulletin, writes on different topics, but is now involved with Flaxseed Meal. If you would like to learn more, please go to our site at Flaxseed Meal.. Check here for free reprint license: Flax Seed Meal ? Can it Reduce the Danger of Cardiovascular Disease?.
Man of the match:?Winless in two games, the Revolution badly needed some early success to blow up their balloon of confidence. New Revs? striker Saer S?ne provided the very antidote around Gillette Stadium, striking on a glancing header just 28 seconds in Saturday. Portland had plenty of chances, but couldn?t do what Sene did so early and efficiently for the home side.
Packaged for take away:
A crowd of 13,000-plus for a home opener? Things aren?t getting any better for the Revs? front office, which is still running ?MLS 1.0? in too many areas.
The supporters who did show for Saturday?s 1-0 win up saw some very encouraging signs. Midfielder Kelyn Rowe, the first-round draft pick out of UCLA, is starting to follow up on a promising preseason with bright nights in the regular season. And Lee Nguyen showed some of his nifty dribbling moves along the left. He can be a real factor in the league if he adjusts his game (which sometimes looks like soccer?s version of hoops? street-ball) to the extra-physical MLS defending.
What club wouldn?t love to have?Shalrie Joseph? Even if the longtime midfield enforcer around Gillette was a little slow to get going in 2012, he?s still one of the league?s top utility knifes. Playing as an emergency center back on Saturday, he was big and strong all evening on Kris Boyd, the Timbers? DP striker. In fact, the two locked up in some great battles. Remember, this is a guy who can and has played at striker for the Revs ? and surely remains one of the league?s premier holding midfielders, his natural spot.
On a couple of instances inside the Revolution penalty area, Joseph did no less than Geoff Cameron did last night to Patrick Ianni on the instance that earned a Sounders? penalty kick. Still, ?you play the game you?re in,? as coaches like to tell players, and in this one it wasn?t a penalty kick.
Portland?s attack will get goals this year, but there are still problems along the outside in defense. Most preseason assessments called left back Rodney Wallace and right back Lovel Palmer the weak links going into 2012, and neither has done much to change anyone?s mind. Neither will remember a Saturday as Gillette Stadium as anything shout about.
Jay Heaps, the second-youngest MLS coach (and not by much), recorded his first win as man in charge. That?s gotta mean a lot to the longtime Revolution defender, who took the top spot this year with full knowledge that a learning curve would be ahead. In fact, everyone can see that. But patience runs out fast, and nobody wants to hear about learning curves when it starts getting really hot in the kitchen. And 0-3 (where the Revs would have been if they had lost Saturday) would already be a mighty hot kitchen. Bottom line: it doesn?t matter than it was a close one, with some steady goalkeeping required of Matt Reis at the end. The Revs had to have this one.
Study identifies genetic variants linked to fatty liver disease in obese children Public release date: 23-Mar-2012 [ | E-mail | Share ]
Contact: Dawn Peters healthnews@wiley.com 781-388-8408 Wiley-Blackwell
New research found the genetic variant Patatin-like phospholipase domain containing protein-3 (PNPLA3) acting in conjunction with the glucokinase regulatory protein (GCKR) is associated with increased susceptibility to fatty liver disease in obese children. The study, published in the March issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, determined the PNPLA3 and GCKR single nucleotide polymorphisms (SNPs) were responsible for up to 39% of the hepatic fat content in this pediatric population.
Obesity is a global health concern and children are not unscathed by this epidemic. As a result, experts say nonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in children and adolescents in industrialized countries. Previous studies indicate genetics significantly impacts the susceptibility of developing fatty liver and nonalcoholic steatohepatitis (NASH), particularly in early-onset disease, which places greater interest on childhood obesity.
For the current study, a team led by Dr. Nicola Santoro from Yale University School of Medicine in New Haven, Connecticut recruited 455 obese children and adolescents who underwent genotyping and fasting triglycerides and lipoprotein particles testing. Participants in this pediatric cohort had a mean age of 13 years with 181 Caucasian, 139 African American and 135 Hispanic children. Researchers measured hepatic fat content (HFF%) using magnetic resonance imaging (MRI) in a subset of 142 children.
Study findings show that rs1260326 in the GCKR gene is associated with higher triglycerides levels and higher levels of very-low-density lipoproteins (VLDL) in Caucasian and African American children. The GCKR SNP was associated with fatty liver in each of the three ethnic groups. A joint effect between PNPLA3 and GCKR SNPs was responsible for 32% of the HFF% in Caucasian, 39% in African American and 15% of Hispanic children. "Our findings confirm that obese youths with genetic variants in the GCKR and PNPLA3 genes may be more susceptible to fatty liver disease. We need to be cautious, though, and refrain to automatically extend this observation to the overall population. In fact, our data refer to a population of obese children and adolescents. I think that further studies involving lean subjects and adults may help to further define in more details these associations," said Dr. Santoro.
In a related editorial, Valerio Nobili with "Bambino Gesu" Children's Hospital and Research Institute in Italy concurs, "Dr. Santoro and colleagues determined the additive effect of PNPLA3 and GCKR variants explained over one third of hepatic fat content variance in obese children." He recommends that ethnicity data be replicated in larger study cohorts due to the small number of participants in each of the three groups.
The study authors suggest that the GCKR variant may lead to accumulation of fat in the liver through an increase in hepatic triglyceride production and further research is warranted to confirm their results. Dr. Santoro concludes, "While the small sample size raises the possibility of false negative results in our study, the presence of both GCKR and PNLPA3 genetic variants acting in combination confers susceptibility to fatty liver disease in obese children."
###
This study and editorial are published in Hepatology. Media wishing to receive a PDF of the articles may contact healthnews@wiley.com.
Full Citations: "A Variant in the Glucokinase Regulatory Protein (GCKR) Gene is Associated with Fatty Liver in Obese Children and Adolescents." Nicola Santoro, Clarence K. Zhang, Hongyu Zhao, Andrew J. Pakstis, Grace Kim, Romy Kursawe, Daniel J. Dykas, Allen E. Bale, Cosimo Giannini, Bridget Pierpont, Melissa M. Shaw, Leif Groop, Sonia Caprio. Hepatology; December 18, 2011 (DOI: 10.1002/hep.24806); Print Issue Date: March 2012. http://onlinelibrary.wiley.com/doi/10.1002/hep.24806/abstract.
Editorial: "Unraveling the genetics of fatty liver in obese children: additive effect of P446L GCKR and I148M PNPLA3 polymorphisms." Luca Valenti, Anna Alisi, Valerio Nobili. Hepatology; December 18, 2011 (DOI: 10.1002/hep.25617); Print Issue Date: March 2012. http://onlinelibrary.wiley.com/doi/10.1002/hep.25617/abstract.
Author Contact: To arrange an interview with Dr. Santoro, please contact Karen Peart with Yale University at karen.peart@yale.edu or 203-432-1326. To speak with Dr. Nobili, please contact Dr. Marco Magheri marco.magheri@opbg.net.
About the Journal
Hepatology is the premier publication in the field of liver disease, publishing original, peer-reviewed articles concerning all aspects of liver structure, function and disease. Hepatology's current impact factor is 10.885.Each month, the distinguished Editorial Board monitors and selects only the best articles on subjects such as immunology, chronic hepatitis, viral hepatitis, cirrhosis, genetic and metabolic liver diseases and their complications, liver cancer, and drug metabolism. Hepatology is published on behalf of the American Association for the Study of Liver Diseases (AASLD). For more information, please visit http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1527-3350.
About Wiley-Blackwell
Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit http://www.wileyblackwell.com or our new online platform, Wiley Online Library (http://www.wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Study identifies genetic variants linked to fatty liver disease in obese children Public release date: 23-Mar-2012 [ | E-mail | Share ]
Contact: Dawn Peters healthnews@wiley.com 781-388-8408 Wiley-Blackwell
New research found the genetic variant Patatin-like phospholipase domain containing protein-3 (PNPLA3) acting in conjunction with the glucokinase regulatory protein (GCKR) is associated with increased susceptibility to fatty liver disease in obese children. The study, published in the March issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, determined the PNPLA3 and GCKR single nucleotide polymorphisms (SNPs) were responsible for up to 39% of the hepatic fat content in this pediatric population.
Obesity is a global health concern and children are not unscathed by this epidemic. As a result, experts say nonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in children and adolescents in industrialized countries. Previous studies indicate genetics significantly impacts the susceptibility of developing fatty liver and nonalcoholic steatohepatitis (NASH), particularly in early-onset disease, which places greater interest on childhood obesity.
For the current study, a team led by Dr. Nicola Santoro from Yale University School of Medicine in New Haven, Connecticut recruited 455 obese children and adolescents who underwent genotyping and fasting triglycerides and lipoprotein particles testing. Participants in this pediatric cohort had a mean age of 13 years with 181 Caucasian, 139 African American and 135 Hispanic children. Researchers measured hepatic fat content (HFF%) using magnetic resonance imaging (MRI) in a subset of 142 children.
Study findings show that rs1260326 in the GCKR gene is associated with higher triglycerides levels and higher levels of very-low-density lipoproteins (VLDL) in Caucasian and African American children. The GCKR SNP was associated with fatty liver in each of the three ethnic groups. A joint effect between PNPLA3 and GCKR SNPs was responsible for 32% of the HFF% in Caucasian, 39% in African American and 15% of Hispanic children. "Our findings confirm that obese youths with genetic variants in the GCKR and PNPLA3 genes may be more susceptible to fatty liver disease. We need to be cautious, though, and refrain to automatically extend this observation to the overall population. In fact, our data refer to a population of obese children and adolescents. I think that further studies involving lean subjects and adults may help to further define in more details these associations," said Dr. Santoro.
In a related editorial, Valerio Nobili with "Bambino Gesu" Children's Hospital and Research Institute in Italy concurs, "Dr. Santoro and colleagues determined the additive effect of PNPLA3 and GCKR variants explained over one third of hepatic fat content variance in obese children." He recommends that ethnicity data be replicated in larger study cohorts due to the small number of participants in each of the three groups.
The study authors suggest that the GCKR variant may lead to accumulation of fat in the liver through an increase in hepatic triglyceride production and further research is warranted to confirm their results. Dr. Santoro concludes, "While the small sample size raises the possibility of false negative results in our study, the presence of both GCKR and PNLPA3 genetic variants acting in combination confers susceptibility to fatty liver disease in obese children."
###
This study and editorial are published in Hepatology. Media wishing to receive a PDF of the articles may contact healthnews@wiley.com.
Full Citations: "A Variant in the Glucokinase Regulatory Protein (GCKR) Gene is Associated with Fatty Liver in Obese Children and Adolescents." Nicola Santoro, Clarence K. Zhang, Hongyu Zhao, Andrew J. Pakstis, Grace Kim, Romy Kursawe, Daniel J. Dykas, Allen E. Bale, Cosimo Giannini, Bridget Pierpont, Melissa M. Shaw, Leif Groop, Sonia Caprio. Hepatology; December 18, 2011 (DOI: 10.1002/hep.24806); Print Issue Date: March 2012. http://onlinelibrary.wiley.com/doi/10.1002/hep.24806/abstract.
Editorial: "Unraveling the genetics of fatty liver in obese children: additive effect of P446L GCKR and I148M PNPLA3 polymorphisms." Luca Valenti, Anna Alisi, Valerio Nobili. Hepatology; December 18, 2011 (DOI: 10.1002/hep.25617); Print Issue Date: March 2012. http://onlinelibrary.wiley.com/doi/10.1002/hep.25617/abstract.
Author Contact: To arrange an interview with Dr. Santoro, please contact Karen Peart with Yale University at karen.peart@yale.edu or 203-432-1326. To speak with Dr. Nobili, please contact Dr. Marco Magheri marco.magheri@opbg.net.
About the Journal
Hepatology is the premier publication in the field of liver disease, publishing original, peer-reviewed articles concerning all aspects of liver structure, function and disease. Hepatology's current impact factor is 10.885.Each month, the distinguished Editorial Board monitors and selects only the best articles on subjects such as immunology, chronic hepatitis, viral hepatitis, cirrhosis, genetic and metabolic liver diseases and their complications, liver cancer, and drug metabolism. Hepatology is published on behalf of the American Association for the Study of Liver Diseases (AASLD). For more information, please visit http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1527-3350.
About Wiley-Blackwell
Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit http://www.wileyblackwell.com or our new online platform, Wiley Online Library (http://www.wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
SAN ANTONIO ? It was a flat tire on the way home from a birthday celebration for his fianc?e. It became an even bigger tragedy.
An alleged drunk driver smashes into the disabled car just after midnight along I-10? as Eric Canales was trying to put a spare on it.
??Wrong place, wrong time. In the blink of an eye, we got hit,? said Canales. ?If I had been still getting stuff from the trunk, I would?ve been hit.?
Authorities say 28-year old Jessica Rodriguez and her 10-year old daughter, Kaylee Flores, were inside the car, struck by a Jeep Cherokee with enough force to crush the Corolla and push it 150 feet.
Canales said, ?I knew in my mind she died instantly on impact. But you don?t want to think that when it?s the person you love.?
Rodriguez was killed. Her daughter later died at the hospital.
Police arrested 25-year old Christopher LaMar, who was behind the wheel of the SUV. Police suspect he had been drinking.
Brandi Rose recognized her friend Jessica?s mangled car from news reports.
?Look what you?ve done; you?ve killed a mother and a daughter. Is it worth it? No,? said Rose.? ?Call a cab. He should?ve been responsible. He was very irresponsible. And through his actions, we lost two, great, amazing people.?
Emergency crews and paramedics who arrived first on the scene could only embrace Canales, as he struggled to understand the few seconds that changed his life forever.
?They were planning a wedding. Now, for what?? added Rose.
Those nuptial plans have been replaced with funeral arrangements ?for two special people.
LaMar remains jailed on two counts of intoxication manslaughter.??
Friends of Rodriguez said?the 28-year old?used to work at the Basement Bar & Lounge on 244 Losoya Street. They plan to take a collection tonight from guests to help defray the funeral costs.
Rose said the family has set up a trust through Security Service Federal Credit Union under Jessica Rodriguez's name.
Our homes must be decorated well in an effort to make it look nicer and perfect. With this you must have your own concepts and inventiveness. You need not worry about the cost as LEDs are here in several forms to match your vision as well as your residence. LEDs are the cost effective way of lighting up your homes in the modern decorating model. Different types of LED lighting are obtainable which are appropriate for your room. A kitchen is the life of a house. It is most persistently used spot in a house, where the family meal is done and general family sits together to to eat their food as one. It is a space where the family shares its memorable moments with their best friends. So it is then so vital that you must be mindful of the lighting in the kitchen area. Having the correct luminosity, can do marvels for your kitchen?s physical appearance and it is possible using LED kitchen lighting.
In terms of LED kitchen lighting, you should ensure that there exists ceiling lighting along with lighting fixtures in particular work places. There are various kinds of lighting fixtures that are available today which can enrich the visual appeal of the kitchen while being sure that there is appropriate light to be able to make everyone satisfied.
You will find some principles that draws your thoughts to the kitchen lighting that put emphasis on successful household lighting concepts but can be more extreme in the way it demands various models of lighting for different zones. Modern LED kitchen lighting is adequate to most kitchen lighting applications. When we think of kitchen lighting there are some things which should be given styles.
Kitchen lighting design typically ought to have clean, crisp light with good CRI as varied zones of the dining room needs different kind of light. In the work place we may need intense light; when preparing food so that you can naturally see what you are working on and what condition it is in but using a fluorescent lamp may not be a good choice as it can certainly cause headache. Some areas only require soft, diffuse ambient light.
LED lights are found in a huge variety of shades which enables the user to experiment by using lights with differing features against different textures and even colors to obtain different effects in specific zones in the kitchen. With LED kitchen lighting, you are confined only by your creative thinking and not by something else. You can use LED strip illumination to highlight your accenting plinths, coving, worktops, racks lighting and almost everything else you could think of. Being water-proof also makes them perfect for lighting kitchen areas where water can splash.
With LED kitchen lights you will be impressed of the stunning outcomes which makes specialty lighting in that remarkable room. All to be done is just replace the existing halogen spotlights and also under-cabinet lights with LED kitchen lighting s. All kitchens are to a great point a triumph of illusion. You can make it even more gorgeous by using these wonderful fittings. Work with it and feel the significant difference.
John Reid is, an electrician and advocate in living Green, been helping to promote aGreenSupply.com high quality LED light bulbs products to consumers in saving energy and money just by changing incandescent bulbs to LED light bulbs. Get the full story and reap the rewards TODAY at http://www.aGreenSupply.com
Related posts:
Under Cabinet LED Lighting ?.. Tips On How To Create Difference And Design To All Kitchen.
LED Kitchen Lighting Can Be Both Efficient And Also Desirable
The Significance Of Proper LED Kitchen Lighting Style
Under Cabinet LED Lighting ?.. Tips On How To Create Difference And Design To All Kitchen.
Things To Think About When Choosing Interior LED Home Lighting
The Acer Iconia A510 is coming. We got some hands-on time with it at CES and we were impressed. A 10.1-inch 1080p screen, a Terga 3 quad-core processor, and Ice Cream Sandwich sounds mighty good, and now you can pre-order one. More »
Gogo isn't just tossing its mid-air wireless goodies toward Virgin and American, with US Airways being the latest to join the extra perks party. Per today's announcement, the airline is stuffing Gogo WiFi in a few more planes, including the Airbus A319 and A320. Other shorter (and much smaller) aircraft, the Embraer 170, 175 and 190, are also getting the in-flight WiFi treatment. Meanwhile, a quick peek at the PR below reveals Gogo is quietly launching its Vision service, allowing passengers to watch movies, shows and have access to "exclusive" shopping deals -- though, you'll have to shell out $1 to $6 more for the privilege. Maybe now you'll actually want to seek out Express flights rather than avoid them, since you'll have far fewer passengers to fight for bandwidth.
[ [ [['Witnesses said the gunman pulled up on a black scooter', 7]], 'http://yhoo.it/GzwOIW', '[Related: New York police tighten security at Jewish sites]', ' ', '630', ' ', ' ', ], [ [['test Zimmerman for alcohol or drugs', 11]], 'http://yhoo.it/Gzn6VF', '[Related: White House says Trayvon Martin is local issue]', ' ', '630', ' ', ' ', ], [ [['Shortly after he wrapped up his victory remarks', 2]], 'http://news.yahoo.com/photos/4-straight-romney-wins-washington-gop-caucus-1330835515-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/3/e9/3e9b0082c3c3111dcc19e3527ae94cc7.jpeg', '500', ' ', 'AP Photo/Steven Senne', ], [ [['best understands the problems of average Americans', 2]], 'http://news.yahoo.com/photos/4-straight-romney-wins-washington-gop-caucus-1330835515-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/3/e9/3e9b0082c3c3111dcc19e3527ae94cc7.jpeg', '500', ' ', 'AP Photo/Steven Senne', ], [ [['Trayvon Martin', 7]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120320/trayvonjquery.jpg', '630', ' ', 'AP', ], [ [['Group for Historic Aircraft Recovery', 7]], 'http://yhoo.it/GB2RVy', 'Click image to see more photos', 'http://l.yimg.com/os/152/2012/03/20/photo-1332257995646-4-0-jpg_171722.jpg', '630', ' ', 'AFP', ], [ [['A massive manhunt is underway in France on Monday', 4]], 'http://yhoo.it/Gzy0M9', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/d/b4/db49ba9fa9a9bb5b59d2503822dd212c.jpeg', '630', ' ', 'AP/Manu Blondeau', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]
[ [ [['French police stepped up the search',17]], ', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]
This is a discussion on New Job, Need to move and break my lease within the Real Estate and Property Law Questions forums, part of the Legal Questions & Answers Forum category; The clause to break my lease reads, "Resident agrees to pay X dollars to defray Management administrative and marketing costs if resident does either of the following: (1) fails to ...
The clause to break my lease reads, "Resident agrees to pay X dollars to defray Management administrative and marketing costs if resident does either of the following: (1) fails to fulfill the agreed upon term of the Apartment Rental agreement or, (2)fails to deliver a written "Vacate Notice" to management at least 60 days prior to move out." My landlord is telling me that I cannot simply pay the penalty and leave, but that I have to pay two months for the two months notice, and then the penalty fee on top of that. Based on the wording of the termination clause, what am I required to do?
Senior Member
Achievements:
Awards:
If you are leaving, prior to the end of your lease, as you indicate, you fall under clause 1 and owe the expenses in addition to the 60 day rental notice period.
You can plan a wonderful kid?s birthday party whenever you adhere to a few basic but helpful planning suggestions. Your kids honestly just want to have a good time with their friends, so it?s not necessary to plan an extravagant party with too many decorations and food to create an exciting party for your child. The following are some kid?s birthday party planning tips to help you organize a fun event.
Plan Ahead and Stay Calm
Many parents make the mistake of waiting until the last minute to do many things for the party that could have been accomplished in advance. There?s no need to run around in a rush when you can start planning the party literally months in advance. Starting early by creating a ?to do? list allows you enough time to get it all together and remain stress free and happy on the day of the party.
Save the Date
Most often a kid?s birthday party will not be scheduled on the exact birthday of the child because it falls in the middle of the work week. Check the calendar to make certain that the date you are planning on will not conflict with other activities going on. If there are other good friends or family members with the same birthday, make sure their party or fun activity isn?t planned for the same date. Also, carefully consider the time of the party; toddler birthday parties are best held when the kids will not require naps etc.
Planning the Theme of Your Kid?s Birthday Party
Kids love a birthday party that includes their favorite character or toy theme. Toddler birthday parties are easy to decorate because there are so many adorable toddler party themes available in decorations, invitations and cakes etc. Older kids may want to have more input in the planning of the theme, so be sure to ask them what they would prefer before selecting a theme and buying party supplies.
Creating the Party Guest List
Deciding on who to invite or how many kids to invite to the party will frequently be determined by the location and age of the child. A common rule of thumb is to invite the same number of guests as the actual age of the child. This is probably a good idea if the space available is restricted or limited. Simply invite the number of kids that you feel you can manage during the party as well as any added expense a large number of kids may incur.
Deciding on the Birthday Party Location
Depending on the number of kids and the ages, you may want to have the party at your own home or the home of a family member. If your budget allows, consider having the party at a park, rec center or restaurant. Some locations will offer party packages where the decorations, food and cake are included in one price. Scheduling well in advance is usually required for party rooms and activity centers.
These are just a few simple tips and suggestions for planning a great kid?s birthday party, but following them and preparing well can help make for a great party and fun time for your child and their friends.
Throw a fun and memorable kid?s birthday party with tips and helpful ideas from Toddler Birthday Party Ideas http://toddler-birthday-party-ideas.com
?Mail this post 
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 23-Mar-2012
Share ] 
